Sepsis is life-threatening!


Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. The occurrence of sepsis is increasing at an annual rate of 1.5%, making it a significant global healthcare concern. Sepsis has a high mortality rate, killing more individuals than prostate cancer, breast cancer and HIV/AIDS combined. 1,2,3.

The facts about sepsis

  • 1.7 million people are diagnosed with sepsis each year in the U.S.4
  • 20% of patients with sepsis are re-hospitalized within 30 days.5

 

Providing Data to Drive Life-saving Decisions:

There’s large unmet clinical need for the early detection of sepsis. Innovative diagnostic solutions can provide valuable and actionable information to clinicians to aid in escalating and de-escalating patient care.

Monocyte Distribution Width (MDW), proprietary to Beckman Coulter analyzers, is the only regulatory-cleared hematological biomarker that helps establish severity of infection and risk of sepsis in adult patients in the emergency department. MDW is a measure of increased morphological variability of monocytes in response to bacterial, viral or fungal infections.

MDW is reported automatically as part of a routine CBC with Differential test on the DxH 900 and DxH 690T hematology analyzers using the Early Sepsis Indicator (ESId) application, which enables automatic reporting with no workflow changes or need to order an additional test.6


“By including MDW in our thought process, we can potentially uncover an underlying sepsis that could have been otherwise missed, especially when other causes can explain a patient’s symptoms.”
NIMA SARANI, M.D.
UNIVERSITY OF KANSAS MEDICAL CENTER 7



References:

  1. https://www.globaldata.com/store/report/severe-sepsis-and-septic-shock-epidemiology-analysis/
  2. Jones SL et al. “Reductions in Sepsis Mortality and Costs After Design and Implementation of a Nurse-based Early Recognition and Response Program.” Jt Comm J Qual Patient Saf, vol. 41, no. 11. 2015, pp. 483–91
  3. Judd WR, Stephens DM, Kennedy DA. “Clinical and Economic Impact of a Quality Improvement Initiative to Enhance Early Recognition and Treatment of Sepsis.” Ann Pharmacol, vol. 48, no. 10. 2014, pp. 1269–75
  4. https://www.cdc.gov/sepsis/what-is-sepsis.html
  5. Liang, L. et al. National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2017. 2020 Jul 14. In: Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]. Rockville (MD): Agency for Healthcare Research. Accessed July 29, 2022
  6. https://www.beckmancoulter.com/en/products/hematology/early-sepsis-detection
  7. https://www.beckmancoulter.com/en/products/hematology/early-sepsis-indicator